Double Stemcell For Thyroid Cancer

Double Stem cell Despite the overall low mortality rate of thyroid cancer, poorly differentiated thyroid carcinoma and ATC rank among the most deadly of all human cancers. This high mortality rate is partially due to the high rate of resistance to conventional cancer therapies.

ebay2

 

According to the classic multi step carcinogenics model, poorly differentiated thyroid carcinomas derive from well-differentiated ones through the sequential accumulation of genetic alterations.

presentation11

Indeed, occurrence of novel mutations into well-differentiated thyroid carcinomas results in a deregulation of several signaling pathways and, as a consequence, a differentiation process and a marked epithelial-to-hymeneal transition.

This hypothesis is supported by the common observation that in many poorly differentiated and ATC specimens, well-differentiated thyroid cancer of funicular origin may also be present.

Moreover, further evidence does not support a multi-step model of thyroid cancer: first, mature thyroid funicular cells undergo a limited number of replications (eight to ten during the lifespan), thereby reducing the possibility of accumulating mutations for transformation; second, some genetic alterations that are present in well-differentiated thyroid carcinomas, such as RET/PTC and the PAX8/PPAR-γ rearrangements, are not found in poorly differentiated thyroid carcinomas.

image25image24

 

However, novel evidence is emerging that cancer cells within a given tumor are not homogeneous and support a stem cell model for thyroid carcinogens and cancer progression.

image14.png image15.png

The cancer stem cell model implies a hierarchical organization of cancer cells and that only a subset of cancer cells can self-renew, giving rise to progenitor cells that may drive tumor growth.

group2

These cells are also believed to give rise to poorly differentiated thyroid carcinomas. Cancer stem cells are believed to be the driving force of tumors as they posses the ability both to undergo self-renewal and to differentiate into various cancer cell types.

 

In this view, they may also play a major role in metastasis and resistance to chemo- and radio-therapy.

Cancer stem cells have been found in several solid tumors including thyroid cancer and it is reasonable to suppose that current therapeutics may not effectively target thyroid cancer stem cells  in poorly differentiated thyroid carcinomas.

grtoup.png

Advertisements

4 thoughts on “Double Stemcell For Thyroid Cancer

  1. SIR ,IS IT THAT THE GOITRE PATIENT WILL TAKE ONLY 2PACKETS OF DOUBLE STEM CELL AND WITHIN 3 TO 4 MONTHS SHE WILL SEE RESULT

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s