Double Stemcell for Treatment of Asthma

Asthma is a general constant provocative sickness of the airways characterized by indication including out of breath, coughing, chest tautness, as well as smallness of breath, reversible airflow impediment, and borne spasm. Asthma is clinically classified according to the frequency of symptoms, forced expiratory volume in 1 second (FEV1), and peak expiratory flow rate. Asthma can also be either exercise induced or occupational. Asthma affects an estimated 300 million people worldwide and causes about 250,000 deaths per year.

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In the United States, asthma affects approximately 26 million people – including almost 10 percent of our children. Asthma causes patients to experience wheezing, shortness of breath, and gasping for air. The incidence of Asthma is rapidly skyrocketing – over the last 25 years the incidence of asthma has more than doubled. Asthma is a highly inflammatory disease often requiring strong inhalers and corticosteroids to stop the inflammatory response.

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At the Miami Stem Cell Treatment Center, we have stem cell treatment options for Asthma that involves the patient’s own adult stem cells; the IRB approved protocol includes a combination of intravenous and nebulized SVF delivery.

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Using our stem cell treatment options, the stem cells are isolated from a small amount of fat–the richest source of stem cells – which are obtained during a mini-liposuction procedure. The stem cells are harvested, concentrated and then deployed (re-infused) back into the patient’s body via intravenous infusion – all in an outpatient procedure. The procedure takes less than two hours.

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We are proud to be part of the only Investigational Review Board (IRB)-based stem cell treatment network in the United States that utilizes fat-transfer surgical technology. We have an array of ongoing IRB-approved protocols, and we provide care for patients with a wide variety of disorders that may be treated with adult stem cell-based regenerative therapy.

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A new study published online in the March 15-19 early edition of the Proceedings of the National Academy of Sciences borrowed its idea from the field of organ transplantation, where multipotent stem cells in the form of bone marrow transplants are already used to reduce the risk of rejection in patients who have received donated organs.

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Senior study author Dr. Eva Mezey, head of the adult stem cell unit at the National Institute of Dental and Craniofacial Research (NIDCR), cautioned that this was an early-stage experiment conducted only in mice, and humans shouldn’t get too excited just yet.

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“On the one hand, people should be cautious that it might not be just as good in people. However, there are many human studies that have proven that these cells are able to modulate the immune system and tip the balance back to normal when the balance is gone,” she said. “It’s very likely that the intervention would work in humans.”

 

But clinical trials will depend on working out numerous details, including how the therapy would be delivered. In the mice, the stem cells were injected but aerosol administration might work better in humans, producing a more local result instead of systemic effects and, probably, fewer side effects, she noted.

And this stem cell therapy, if it ever reaches patients, is likely to be reserved for those who haven’t responded to other therapies. “Basically, you would think of this therapy in cases where patients are resistant to existing treatment,” Mezey explained.

Some 16 million people in the United States have asthma, and the incidence seems to be on the rise.

Because bone marrow transplants quell immune responses in transplant patients, the idea was that it might be beneficial in individuals with other immune-based diseases such as asthma.

Here, the investigators used mice that had been engineered to be allergic to ragweed and injected them with multipotent stem cells known as bone marrow stromal cells. Multipotent stem cells are cells that can develop into many different cell types.

Indeed, animals injected with the compound had fewer allergy and asthma symptoms when exposed to the allergen, ragweed.

“We gave the mice intravenous injections of stem cells and, after four days, we assessed different mediators of the inflammatory response and that’s how we could pick up the beneficial effects of the stem cells,” said study first author Dr. Krisztian Nemeth, a research fellow with the adult stem cell unit of NIDCR.

After that, he added, “we went into more accurate details and tried to explore what anti-inflammatory molecules were synthesized by our cells and how they mediated the anti-inflammatory response.”

It turned out that the stem cells righted the balance of certain white blood cells that are out of sync in those with asthma.

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